GnRH Analogues and Puberty Blockers
GnRH analogues are medications that suppress the body's production of sex hormones. They are used in various contexts, including as puberty blockers and as part of adult HRT regimens.
Disclaimer: This information is for educational purposes only and does not constitute medical advice. Always consult with your healthcare provider before making any changes to your medication.
What Are GnRH Analogues?
GnRH (gonadotropin-releasing hormone) analogues work by suppressing the pituitary gland's release of LH and FSH, which in turn reduces the body's production of oestrogen or testosterone. This effectively pauses hormonal activity.
GnRH Analogues Tracked in Gender Journey
The app supports tracking the following:
- Leuprolide Acetate — Administered by injection, typically monthly or every three months.
- Goserelin Acetate — An implant administered under the skin, usually monthly or every three months.
- Triptorelin — Administered by injection, with similar dosing intervals.
Puberty Blockers
For younger individuals, GnRH analogues are sometimes prescribed to pause puberty, giving more time for exploration and decision-making. Gender Journey tracks:
- Leuprolide Acetate — Also used as a puberty blocker at appropriate doses.
- Histrelin Acetate (Implant) — A small implant placed under the skin, typically lasting around one year.
How They Are Used
- Standalone — Some individuals use GnRH analogues without other hormones to achieve a more neutral hormonal state.
- With HRT — Others use them alongside oestrogen or testosterone to fully suppress endogenous hormone production.
- As a bridge — GnRH analogues can provide time for decision-making before starting cross-sex hormones.
Monitoring
Regular monitoring is important while on GnRH analogues:
- Hormone levels — LH, FSH, oestradiol, and testosterone to confirm suppression.
- Bone density — Long-term use may affect bone health; discuss monitoring with your provider.
- General health markers — Full blood count, liver function, and other routine tests.
Tracking in Gender Journey
Add your GnRH analogue to My Medications with the correct dose and frequency. Set reminders for injection or implant dates, and log your blood test results in My Health to monitor suppression.